Paul D. Drew, Ph.D.

Title
Professor

Ph.D.
University of Maryland

Post Doctoral Training
National Institutes of Health

Major Interests
Regulation of the immune response in neurodegenerative disorders including multiple sclerosis

Research Interests
Dr. Drew conducts research in the field of Neuroimmunology. Normally, immune activity in the brain is limited. However, in diseases including multiple sclerosis, Alzheimer’s disease, and alcohol abuse activated immune cells are observed in the brain. These immune cells produce cytokines which may be toxic to brain cells as well as chemokines which direct cells to sites of inflammation, resulting in neuropathology. Dr. Drew’s research involves modern cellular and molecular biology techniques.

Curriculum Vitae: Word

Email: drewpauld@uams.edu

Address: Office: Biomedical Research Building II, Room 563-2
Mailing address: University of Arkansas for Medical Sciences
4301 W. Markham, Slot Slot 846
Little Rock, AR 72205

Phone: 501-686-1265

Fax: 501-526-6756

Selected Publications

Kane, C.J.M., K.D. Phelan, L. Han, R.R. Smith, J. Xie, J.C. Douglas, and P.D. Drew. 2011. Protection of neurons and microglia against ethanol in a mouse model of fetal alcohol spectrum disorders by peroxisome proliferator activated receptor gamma ligands. Brain Behavior and Immunity. 25:S137-S145.

Kane, C.J.M., K.D. Phelan, and P.D. Drew, 2011. Chapter 147. Molecular Targets of Ethanol in the Developing Brain. Encyclopedia of Addictive Behaviors, Peter Miller, ed. Elsevier Limited, Oxford, UK.

Solt, L.A., N. Kumar, P. Nuhant, Y. Wang, J.L. Lauer, J. Liu, M.A. Istrate, T.M. Kamenecka, W. R. Roush, D. Vidovic, S. C. Schurer, J. Xu, G. Wagoner, P.D. Drew, P. R. Griffin, and T.P. Burris. 2011. Inhibition of T(H)17 differentiation and suppression of autoimmunity by a selective ROR ligand. Nature. 472:491-494.

Drew, P.D., and C.J.M. Kane. 2012. Neuroimmune Mechanisms in Glia and their Interplay with Alcohol Exposure across the Lifespan, in Neural-Immune Interactions in Brain Function and Alcohol Related Disorders, Springer, New York.

Xu, J., G. Wagoner, J.C. Douglas, and P.D. Drew. 2013. β-Lapachone ameliorization of experimental autoimmune encephalomyelitis. J. Neuroimmunology. 254:46-54.

Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, and P.D. Drew. 2013. Effects of ethanol on immune response in the brain: region specific changes in aged mice. J. Neuroinflammation. 10:66-69.

Kane, C.J.M., K.D. Phelan, J.C. Douglas, G. Wagoner, J. Walker-Johnson, J. Xu, P.S. Phelan, and P.D. Drew. 2013. Effects of ethanol on immune response in the brain: region specific changes in adolescent versus adult mice. Alcohol Clin. Exp. Res. In press.

Link to Dr. Drew’s PubMed publications