Angela Odle, Ph.D.

Angela Odle, Ph.D.

Title 
Assistant Professor

Ph.D.
University of Arkansas for Medical Sciences

Post Doctoral Training
University of Arkansas for Medical Sciences

Major Interests
Reproductive Endocrinology and Metabolism

Research Interests
Dr. Odle’s research is centered at the intersection of reproduction and metabolism, specifically at the level of the pituitary.  The lab is particularly interested in how the metabolic hormone leptin influences the development and function of the gonadotropes (LH- and FSH- secreting cells) in females.  Using a combination of transgenic models and molecular techniques, Dr. Odle aims to determine the actions of metabolism on the development of this reproductive pituitary cell network.

Curriculum Vitae: AO Curriculum Vitae 2019.docx

Email: akodle@uams.edu

Address: Office: Biomedical Research Building II, Room 661-2
Mailing address: University of Arkansas for Medical Sciences
4301 W. Markham, Slot Slot 846
Little Rock, AR 72205

Phone: 501-296-1367

Selected Publications

Odle AK, Beneš H, Melgar Castillo A, Akhter N, Syed M, Haney A, Allensworth-James M, Hardy L, Winter B, Manoharan R, Syed R, MacNicol MC, MacNicol AM, Childs GV. Association of Gnrhr mRNA With the Stem Cell Determinant Musashi: A Mechanism for Leptin-Mediated Modulation of GnRHR Expression. Endocrinology. 2018 Feb 1; 159(2): 883-894. PMID: 29228137

Odle AK, Akhter N, Syed MM, Allensworth-James ML, Beneš H, Melgar Castillo AI, MacNicol MC, MacNicol AM, Childs GV. Leptin Regulation of Gonadotrope Gonadotropin-Releasing Hormone Receptors As a Metabolic Checkpoint and Gateway to Reproductive Competence. Front Endocrinol (Lausanne). 2018 Jan 5; 8: 367. PMID: 29354094

Odle AK, Allensworth-James ML, Akhter N, Syed M, Haney AC, MacNicol M, MacNicol AM, Childs GV. A Sex-Dependent, Tropic Role for Leptin in the Somatotrope as a Regulator of POU1F1 and POU1F1-Dependent Hormones. Endocrinology. 2016 Oct; 157(10): 3958-3971. PMID: 27571135

Odle AK, Allensworth-James M, Haney A, Akhter N, Syed M, Childs GV. Adipocyte Versus Somatotrope Leptin: Regulation of Metabolic Functions in the Mouse. Endocrinology. 2016 Apr; 157(4): 1443- PMID: 26859333

Odle AK, Haney A, Allensworth-James M, Akhter N, Childs GV. Adipocyte versus pituitary leptin   in the regulation of pituitary hormones: somatotropes develop normally in the absence of circulating leptin. Endocrinology. 2014 Nov; 155(11): 4316-28. PMID: 25116704

 

Link to Dr. Odle’s Publications