Jason Y. Chang, Ph.D.

Associate Professor of Neurobiology & Developmental Sciences, OphthalmologyJason Y. Chang, Ph.D.

Ohio State University

Post Doctoral Training
Washington University, St. Louis, MO

Research Interests
1. Basic Research: Apoptosis. Neuronal and glial cell death caused by trophic factor deprivation, oxidative stress, organic or inorganic cytotoxic agents.
2. Clinical Research: The effect of Tai Chi, a moving meditation derived from ancient Chinese martial art, on osteoarthritic pain and quality of life in elders with cognitive impairment.

Email: changjasony@uams.edu

Address: Office: Shorey 924
Mailing address: University of Arkansas for Medical Sciences
4301 W. Markham, slot 510
Little Rock, AR 72205

Phone: 501-686-7025

Fax: 501-686-6382

Selected Publications

1. Chang, J.Y. Bora, P.S and Bora, N.S.  Prevention of oxidative stress induced RPE cell death by the PPARg agonist, 15-deoxy-delta 12, 14-Prostaglandin J2 PPAR Research 2008; 2008:720163

2. Chang, J.Y. and Tsai, P. Prevention of MeHg-induced mitochondrial depolarization, glutathione depletion and cell death by 15-deoxy-delta-12,14-prostaglandin J2. Neurotoxicology 2008: 29: 1054-1061

3. KaneC.J.M., Chang, J.Y.,  Paula K. Roberson, P.K., Garg, T. and Han, L.  Ethanol exposure of neonatal rats does not increase biomarkers of oxidative stress in isolated cerebellar granule neurons. Alcohol 2008; 42:29-36.

4. Tsai, P., Beck, C., Chang, J.Y., Hagen, J., Anand, S., Kuo, Y., Roberson, P., Rosengren, K., & Beuscher, L., & Doan, C.. The effect of Tai Chi on knee osteoarthritis pain in cognitively impaired elders: Pilot study. Geriatric Nursing 2009; 30: 132-139

5. Tsai, P., Chang, J.Y., Beck, C., Hagen, J., Anand, K.J.S., Kuo, Y.F., Roberson, P.K., Rosengren, K., Beuscher, L. The feasibility of implementing Tai Chi for nursing home residents with knee osteoarthritis and cognitive impairment. Activities Directors’ Quarterly for Alzheimer’s & Other Dementia Patients 2009: 10(1), 9-17.

6. Chang, J.Y., Tsai, P. IL-6 release from mouse glia caused by MeHg requires cytosolic phospholipase A2 activation. Neurosci. Lett. 2009; 461: 85-89

7. Tsai, P., Chang, J.Y., Chowdhury, N., Beck, C., Roberson, P.K., Rosengren, K. Enrolling Older Adults with Cognitive Impairment in Research: Lessons from a Study of Tai Chi for Osteoarthritis Knee Pain. Res. Gerontol. Nursing. 2009; 2: 228-234.

8. Chang, J.Y., Tsai, P., Woods, S., Beck, C., Roberson, P.K., Rosengren, K.  Teaching of Tai Chi to elders with osteoarthritis pain and mild cognitive impairment. Activities Directors’ Quarterly for Alzheimer’s & Other Dementia Patients 2010; 11(4): 8-17. (per Editor’s request, concurrently  published in American Journal of Recreational Therapy, 2011:10: 11-16)

9. Chang, J.Y., Tsai, P., Beck, C. Hagen, J., Huff, D.C., Anand, K.J.S., Roberson, P.K., Rosengren, K., Beuscher, L. Pilot testing the effect of Tai Chi on cognition in elders with cognitive impairment. Medsurg Nursing 2011; 20 (2): 63-69.

10. Chang, J.Y. Not only concentrations matter: Some practical considerations of in vitro MeHg toxicity studies. In Book Title: Methylmercury: Formation, Sources and Health Effects, by Nova Publishers. Andrew P. Clampet, editor. 2011, Chapter 5, page 97-108.

11. Chang, J.Y. Methylmercury induced IL-6 release requires Phospholipase C activities. Neurosci. Lett. 2011; 496: 152-156.

12. Brown, G., Siegel, E., Staples, S. Doyle, J., Chang, J.Y. Diabetes and Corneal endothelial cell characteristics: a study based on Eye Bank data. Eye Reports 2011; 1: e9