Kevin D. Phelan, Ph.D.

Kevin D. Phelan, Ph.D.Title

Michigan State University

Post Doctoral Training
– Dept. of Pharmacology and Toxicology
University of Texas Medical Branch, Galveston, TX
– Dept. of Pharmacology
University of Medicine and Dentistry of New Jersey, Piscataway, NJ
– Dept. of Neurology
University of Pennsylvania School of Medicine, Philadelphia, PA

Research Interests
Regulation of Synaptic Transmission and Ethanol Effects on the Brain. The physiology and pharmacology of normal synaptic transmission is studied as a basis for understanding dysfunction that may occur in various neurological diseases. State-of-the-art electrophysiological methodologies, including intracellular and patch clamp recording, are used to examine the mechanisms underlying synaptic transmission between developing and adult neurons in tissue culture and rodent brain slice models. Current areas of interest include: presynaptic and postsynaptic mechanisms of modulation of excitatory and inhibitory synaptic events; the contribution of intrinsic membrane properties and conductances to neuronal excitability; mechanisms of seizure-induced neurodegeneration; and effects of alcohol on the CNS throughout the lifespan.


Address: Office: Biomedical Research Building II – Room 564-2

Mailing address: Department of Neurobiology and Developmental Sciences – Slot 846
University of Arkansas for Medical Sciences
4301 W. Markham St.
Little Rock, AR 72205

Phone: (501) 686-8192

Fax: (501) 526-6756

Link to Dr. Phelan’s Pubmed publications

Selected Publications

1)    Kane, C.J.M., K.D. Phelan, L. Han, R.R. Smith, J. Xie, J.C. Douglas, and P.D. Drew (2011) Protection of Neurons and Microglia Against Ethanol in a Mouse Model of Fetal Alcohol Spectrum Disorders by Peroxisome Proliferator Activated Receptor-g Agonists, Brain Behavior and Immunity 25:S137-S145.
2)    Kane, C.J.M., K.D. Phelan, and P.D. Drew (2012) Neuroimmune mechanisms in fetal alcohol spectrum disorder, Developmental Neurobiology 72:1302-1316.
3)    Phelan, K.D., M.M. Mock, O. Kretz, U T. Shwe, M. Kozhemyakin, L. J. Greenfield, A. Dietrich, L. Birnbaumer, M. Freichel, V. Flockerzi, and F. Zheng (2012) Heteromeric Transient Receptor Potential 1 and 4 channels play a critical role in epileptiform burst firing and seizure-induced neurodegeneration. Molecular Pharmacology, 81:1-9.
4)    Phelan, K.D., U. T. Shwe, J. Abramovits, H. Wu, S. Rhee, M. Howell, P. Gottschall, M. Freichel, V. Flockerzi, L. Birnbaumer, and F. Zheng (2013) Canonical transient receptor channel 5 (TRPC5) and TRPC1/4 contribute to seizure and excitotoxicity by distinct cellular mechanisms. Molecular Pharmacology 83:429-438.
5)    C.J. M. Kane, K. D. Phelan, J. C. Douglas, G. Wagoner, J. W. Johnson, J. Xu and P. D. Drew (2013) Effects of Ethanol on Immune Response in the Brain: Region Specific Changes in Aged Mice. J. Neuroinflammation 10:66.
6)    C.J.M. Kane, K. D. Phelan, J. C. Douglas, G. Wagoner, J. W. Johnson, J. Xu, P. S. Phelan and P. D. Drew. Effects of Ethanol on Immune Response in the Brain: Region Specific Changes in Adolescent versus Adult Mice. Alcohol Clin. Exp. Res. (in press).