M. Donald Cave, Ph.D.

M. Donald Cave, Ph.D.Title
Professor Emeritus

Post Doctoral Training
Postdoctoral Fellowships, Genetics Institute, Lund Sweden and Max-Planck-Institute, Tubingen, West Germany.

Major Interests
Probes for the diagnosis and molecular epidemiology of diseases caused by bacterial pathogens

Research Interests
M. Donald Cave’s work was directed towards the development of molecular biology based tests for microbial pathogens. Particularly was involved in development of tests for mycobacterial pathogens (e.g. Mycobacterium tuberculosis) and for certain food-borne pathogens (e.g. Salmonella spp. and Campylobacter spp). In collaboration with K. D. Eisenach, Ph.D. (Dept. of Pathology) and J.H. Bates, M.D. (Arkansas Department of Health) a rapid test for identifying M. tuberculosis in clinical samples and a means for fingerprinting strains of M. tuberculosis were developed.

Curriculum Vitae: Word

Email: dcave@uams.edu

Address: Office: Shorey Building 922
Mailing Address:Department of Neurobiology and Developmental Sciences, #510
University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205-7199

Phone: 501-686-5165

Fax: 501-296-1267

Selected Publications

Luzze, H., Johnson, D.F., Dickman, K., Mayanja-Kizza, H., Okwera, A., Eisenach, K., Cave, M.D., Whalen, C.C., Johnson, J.L., Boom, W.H., and Joloba, M. 2013. Relapse more common than reinfection in recurrent tuberculosis 1–2 years post treatment in urban Uganda.  International Journal of Tuberculosis and Lung Disease 17(3):361–367.

Dickins, A. M., Franklin, S., Stefanova, R., Schutze, G. E. Eisenach, K. D., Wesley, I., and Cave, M.D. 2002. Diversity of Campylobacter Isolates from Retail Poultry Carcasses and from Humans as Demonstrated by Pulsed Field Gel Electrophoresis. J. Food Protection 65, 957-962.Barnes, P. F. and Cave, M.D. 2003. Molecular epidemiology of tuberculosis: relevance to disease control and pathogenesis. New England Journal of Medicine 249, 1149-1156.

Theus, S.A., Cave, M. D.and Eisenach, K.D. 2005. Intracellular macrophage growth rates and cytokine profiles of M. tuberculosis strains with different transmission dynamics. J. Infect Dis. 191, 453-460.

M.D. Cave, Yang, ZH, Stefanova, R., Fomukong, N., Ijaz, K., Bates, J., and Eisenach K.D. 2005. Epidemiologic import of tuberculosis cases whose isolates have similar but not identical IS6110 RFLP patterns. J. Clin. Microbiol 43, 1228-1233.

Filliol I, Motiwala, AS, Cavatore, M, Qi, W, Hazbón, M, Bobadilla del Valle, M, Fyfe, J, García-García, L, Rastogi, N, Sola, C, Brudey, K, Zozio, T, Guerrero, MI, Leon, CI, Crabtree, J, Angiouli, S, Eisenach, KD, Durmaz, R, Joloba, M, Rendon, A, Sifuentes-Osornio, J, Ponce de León, A, Cave, MD, Fleischmann, R, Whittam, TS, and Alland, D. 2006. Global Phylogeny of Mycobacterium tuberculosis based on Single Nucleotide Polymorphism (SNP) Analysis: Insights into Tuberculosis Evolution, Phylogenetic Accuracy of other DNA Fingerprinting Systems, and Recommendations for a Minimal Standard SNP Set. J. Bacteriology 188, 759-772.